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Systemic Lupus Erythematosus

Overview

SLE - a severe systemic disease of connective tissue immune nature in which the affected skin and various internal organs. 90% of patients were women aged 20-40 years. The prevalence of disease among members of different races and ethnic groups varies: most often seen in SLE blacks and lowest among whites. The disease is chronic with periods of relapse and require long-term anti-inflammatory therapy.

The name of the disease was due to its characteristic features, and a rash on the cheeks, which, as previously thought, like wolf bites.

The causes of the disease

The cause of lupus is unknown. The disease is a chronic autoimmune inflammation associated with development of immune system cells, antibodies against the DNA of the cells of its own body. These antibodies destroy the cells of the connective tissue of various organs and the System Works (skin, kidneys, nervous system, blood vessels, blood cells, heart, lungs, gastrointestinal tract, eyes), which explains the wealth of clinical manifestations of SLE.

Symptoms of Lupus

SLE may begin with the destruction of any one agency or several at once. Depending on this, the primary will appear or that the symptoms of the disease:

- Pain in muscles and joints;
- Swelling of the hands and feet associated with arthritis of small joints;
- Rash on the cheeks and nose (persistent red spots or patches);
- Discoid lupus thick red scaly patches on the skin of the scalp, ears, face, arms, open areas of the chest and back;
- Patchy hair loss;
- Sores on the mucous membrane of the mouth and nose;
- Increased skin sensitivity to sunlight;
- Depression, anxiety disorders, psychosis;
- Nausea, diarrhea;
- Reduced vision.

Patients also complain of undue rises in temperature, fatigue, headache, fatigue.

Diagnosis of systemic lupus erythematosus

After questioning and detailed examination of the patient the doctor refers the patient for additional testing. The list of necessary diagnostic procedures is determined by the clinical symptoms. In the mandatory blood test performed on antinuclear antibodies and antibodies against the DNA of cells, general and biochemical blood tests and urinalysis.

What you can do?

If you notice in yourself or someone try to SLE symptoms as soon as possible to turn to the therapist. Upon confirmation of the diagnosis should be attentive to the doctor's appointments and to monitor their own well-being.
In patients with SLE are features of the course of pregnancy and childbirth. So if you already have a diagnosis of SLE, and you are going to conceive a child, be sure to check with your doctor.

What can a doctor?

SLE can not be completely cured. The goal of therapy is to combat severe exacerbations and maintain satisfactory condition of the patient in remission. The basis of treatment is anti-inflammatory drugs (NSAIDs, steroids) and cytotoxic immunosuppressive agents. Depending on the clinical manifestations of symptomatic therapy. In some cases, shows extracorporeal detoxification (plasmapheresis, hemosorbtion, cryoplasmasorption).